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The dose-dependent effects of metformin on mitochondrial function underscore the importance of careful dosage management in clinical settings ( Furthermore, it is important to note that the effectiveness of metformin varies depending on the specific tissue and the dosage used ( 4 Unraveling the mechanisms behind metformin's antioxidant properties Metformin can modulate oxidative stress by inhibiting ROS production through pleiotropic actions, including AMPK modulation, mitochondrial complex I inhibition, and increased antioxidant enzyme activity

Biochem J 298: 249258